The positive impact of regular exercise program on stem cell mobilization prior to autologous stem cell transplantation

作者：Keser Ilke^*; Suyani Elif; Aki Sahika Zeynep; Sucak Ayhan Gulsan Turkoz

来源：Transfusion and Apheresis Science, 2013, 49(2): 302-306.

DOI：10.1016/j.transci.2013.06.007

• Hematopoietic stem cell
• Mobilization
• Physiotherapy
• Exercise
• Stem cell transplantation

Aim: The present study was planned to determine the effects of regular exercise program on hematopoietic stem cell (HSC) mobilization prior to autologous stem cell transplantation.
Method: Twenty-two consecutive patients were enrolled in the study. A regular 20 min exercise program was administered to the patients. The hematopoietic stem cell mobilization outcome, number of Granulocyte Colony-Stimulating Factor (G-CSF) and aphaeresis application days were compared with 20 case-matched controls who did not receive exercise program during HSC mobilization.
Results: The median number of CD34(+) stem cells collected in the exercise and control groups were 8.15 x 10(6)/kg (range: 2.85-33.06 x 10(6)/kg) and 7.3 x 10(6)/kg (range: 1.78-25.9 x 106/kg), respectively (p = 0.696). G-CSF was administered for a median of 8 days (range, 5-10) in the exercise group and 8 days (range, 5-12) in the control group (p = 0.848). The median apheresis duration was 1 day (range, 1-3) in both exercise and control groups (p = 0.226).
Conclusion: Exercise seems to have a positive impact on stem cell mobilization though without statistical significance.

• 出版日期2013-10