A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures

作者：Ma Xiaoxiao; Tseng Wei Yu; Eddings Mark; Keng Pei Yuin; van Dam R Michael^*

来源：Lab on a Chip, 2014, 14(2): 280-285.

DOI：10.1039/c3lc50939g

We present a simple microreactor with dimethyl sulfoxide (DMSO) phase-change valves suitable for performing batch organic chemistry under high temperature and pressure conditions. As a proof of principle, we demonstrate a radiofluorination reaction important in the synthesis of [ F-18]FAC, a new positron emission tomography biomarker for immune system monitoring and prediction of chemotherapy response. We achieved high radioactivity recovery (97 +/- 1%, n = 3) and conversion efficiency (83 +/- 1%, n = 3), comparable to that achieved with macroscale systems, but with a volume 30x smaller. This platform overcomes the limitations of previously reported phase-change valves in terms of compatibility with organic chemistry, and extends the range of reaction conditions for carrying out harsh batch chemistry at the microscale.

• 出版日期2014