Utilization of star-shaped polymer architecture in the creation of high-density polymer brush coatings for the prevention of platelet and bacteria adhesion

作者：Totani Masayasu^*; Ando Tsuyoshi; Terada Kayo; Terashima Takaya; Kim Ill Yong; Ohtsuki Chikara; Xi Chuanwu; Kuroda Kenichi; Tanihara Masao

来源：Biomaterials Science, 2014, 2(9): 1172-1185.

DOI：10.1039/c4bm00034j

• Effective approaches
• High-density polymer brushes
• Living radical polymerization
• Phosphate-buffered salines
• Poly(2-hydroxyethyl methacrylate)
• Poly(ethylene terephthalate) (PET)
• Poly(methyl methacrylate) (PMMA)
• Ruthenium catalysts

We demonstrate utilization of star-shaped polymers as high-density polymer brush coatings and their effectiveness to inhibit the adhesion of platelets and bacteria. Star polymers consisting of poly( 2-hydroxyethyl methacrylate) (PHEMA) and/or poly(methyl methacrylate) (PMMA) were synthesized using living radical polymerization with a ruthenium catalyst. The polymer coatings were prepared by simple drop casting of the polymer solution onto poly(ethylene terephthalate) (PET) surfaces and then dried. Among the star polymers prepared in this study, the PHEMA star polymer (star-PHEMA) and the PHEMA/PMMA (mol. ratio of 71/29) heteroarm star polymer (star-H71M29) coatings showed the highest percentage of inhibition against platelet adhesion (78-88% relative to the non-coated PET surface) and Escherichia coli (94-97%). These coatings also showed anti-adhesion activity against platelets after incubation in Dulbecco's phosphate buffered saline or surfactant solution for 7 days. In addition, the PMMA component of the star polymers increased the scratch resistance of the coating. These results indicate that the star-polymer architecture provides high polymer chain density on PET surfaces to prevent adhesion of platelets and bacteria, as well as coating stability and physical durability to prevent exposure of bare PET surfaces. The star polymers provide a simple and effective approach to preparing anti-adhesion polymer coatings on biomedical materials against the adhesion of platelets and bacteria.

• 出版日期2014