Doppler renal resistive index for early detection of acute kidney injury after major orthopaedic surgery A prospective observational study

作者：Marty Philippe^*; Szatjnic Simon; Ferre Fabrice; Conil Jean Marie; Mayeur Nicolas; Fourcade Olivier; Silva Stein; Minville Vincent

来源：European Journal of Anaesthesiology, 2015, 32(1): 37-43.

DOI：10.1097/EJA.0000000000000120

BACKGROUND Postoperative acute kidney injury (AKI) is a cause of morbidity and mortality. Its diagnosis requires better markers than variations in diuresis or postoperative serum creatinine.
OBJECTIVES The aim of this study was to evaluate the accuracy of Doppler renal resistive index for early detection of AKI after hip or knee arthroplasty.
DESIGN A prospective observational study.
SETTING A single-centre study in a university hospital.
PATIENTS Fifty men and women older than 65 years, requiring hip or knee replacement with at least two perioperative AKI risk factors, including diabetes, arteritis, chronic heart or renal dysfunction, and prescription of angiotensin-converting enzyme (ACE) inhibitors. Exclusion criteria were poor abdominal echogenicity, arrhythmia, respiratory failure or agitation.
INTERVENTION Renal resistive index was measured preoperatively and in the postanaesthesia care unit.
RESULTS Sixteen patients presented with AKI in the postoperative period. Resistive index was increased in this group in both the preoperative [0.72 (0.69 to 0.73) vs. 0.66 (0.58 to 0.71); P = 0.01] and postoperative periods [0.75 (0.71 to 0.75) vs. 0.67 (0.62 to 0.72); P = 0.0001]. Resistive index evaluated by ROC curves and AUC to detect AKI was 0.862 [95% confidence interval (95% CI) 0.735 to 0.943]. The most accurate cut-off value was a postoperative resistive index of 0.705 (sensitivity = 94%, specificity = 71%, LR+ = 3.19 and LR- = 0.09). The grey area between 0.705 and 0.73, corresponding to the inconclusive zone, included 26% (13/50) of all the patients.
CONCLUSION Postoperative resistive index appears to be effective for early detection of AKI after major orthopaedic surgery. Resistive index can be measured in the postoperative care unit in patients at risk of AKI.

• 出版日期2015-1