Phenylpropanoid glucosides from Tadehagi triquetrum inhibit oxLDL-evoked foam cell formation through modulating cholesterol homeostasis in RAW264.7 macrophages

作者：Wang, Shuai; Zhang, Xiaopo; Li, Xin; Liu, Qibing; Zhou, Yue; Guo, Peng; Dong, Zhengqi^*; Wu, Chongming^*

来源：Natural Product Research, 2019, 33(6): 893-896.

DOI：10.1080/14786419.2017.1410813

• Phenylpropanoid glucosides
• atherosclerosis
• RAW264
• 7 macrophages
• foam cell formation
• cholesterol efflux
• influx

The phenylpropanoid glucosides from Tadehagi triquetrum were found to be beneficial to glucose and lipid metabolism in vitro. Herein, we investigated the effects of these compounds on oxidised low-density lipoprotein (oxLDL)-induced foam cell formation in RAW264.7 macrophages, aiming to evaluate their potential utility in prevention of atherosclerosis. Our results showed that three out of seven phenylpropanoid glucosides significantly inhibited oxLDL-evoked foam cell formation. These three compounds remarkably inhibited cholesterol influx and enhanced cholesterol efflux. Treatment with compounds 3, 4 and 7 significantly down-regulated the expression of scavenge receptors 1 (SR-1) and cluster of differentiation 36 (CD36) and increased the expression ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1). Analyses of structure-activity relationships revealed that cinnamyl group was the most pivotal group for their activities. This work provided phenomenon that these phenylpropanoid glucosides are effective regulator of cholesterol influx/efflux and may be useful in leading for development of anti-atherosclerotic agents. @@@ [GRAPHICS] @@@ .

• 出版日期2019-3-19
• 单位北京协和医学院; 河北医科大学; 中国医学科学院北京协和医院; 海南医学院