Age-an independent prognostic factor of clinical outcome in renal malignancies: results of a large study over two decades

作者：Hupe Marie C; Merseburger Axel S; Lokeshwar Vinata B^*; Eggers Hendrik; Rott Hendrik; Wegener Gerd; Abbas Mahmoud; Kuczyk Markus A; Herrmann Thomas R

来源：World Journal of Urology, 2014, 32(1): 115-121.

DOI：10.1007/s00345-013-1164-6

• Age
• Renal malignancies
• Treatment
• Prognostic indicators
• Metastasis
• Cancer-specific survival

Age has been linked to outcome in renal cancer patients, but mainly in North American cohorts. In this study, we hypothesized that age is correlated with metastasis and cancer-specific survival in a German cohort regardless of types of treatments. %26lt;br%26gt;A total of 1,538 patients treated for renal malignancies between 1991 and 2010 were evaluated. Mean age and median age are 61.9 +/- A 11.6 and 62.6 years. Clinicopathologic [tumor type, size, grade, stage and treatment (surgery, chemotherapy, radiation, immunotherapy)] and outcome parameters (metastasis and survival) were examined for an association with age using logistic regression and Cox proportional hazard model, and Kaplan-Meier plots. %26lt;br%26gt;Age was associated with stage, metastasis, treatment, cancer-specific and overall mortality (p %26lt; 0.01). The metastasis-free and cancer-free survival rates for patients %26gt; 63 years were lower than those for patients a parts per thousand currency sign63 years (p %26lt; 0.0001). In a multivariate analysis, age was an independent prognostic factor of metastasis, cancer-specific and overall mortality (p %26lt; 0.0001) even when data were stratified in different decades and treatment was included as one of the parameters. Patients %26gt; 63 years of age had 29-35 % higher risk of metastasis and cancer-specific mortality than younger patients. Median metastasis-free and cancer-specific survival for patients %26gt; 63 years of age (months: 84.4; 70.3) was similar to 50 % shorter than in patients a parts per thousand currency sign63 years (months: 151; 144.6). %26lt;br%26gt;This large study shows that, despite advances in surgical and non-surgical treatment modalities over the two decades, age is an independent prognostic indicator of metastasis and cancer-specific mortality in renal cancer patients. Patients %26gt; 63 years have similar to 30 % increased risk for metastasis and similar to 50 % shorter cancer-specific survival.

• 出版日期2014-2