Non-Destructive Evaluation Method of Pharmaceutical Tablet by Terahertz-Time-Domain Spectroscopy: Application to Sound-Alike Medicines

作者：Kawase Masaya^*; Yamamoto Kohji; Takagi Keita; Yasuda Ryohei; Ogawa Masafumi; Hatsuda Yasutoshi; Kawanishi Sonoyo; Hirotani Yoshihiko; Myotoku Michiaki; Urashima Yoko; Nagai Katsuhito; Ikeda Kenji; Konishi Hiroki; Yamakawa Junji; Tani Masahiko

来源：Journal of Infrared Millimeter and Terahertz Waves, 2013, 34(9): 566-571.

DOI：10.1007/s10762-013-9994-2

• THz-TDS
• Non-destructive method
• Sound-alike medicine
• Medical security maintenance
• Pharmaceutical tablet

To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

• 出版日期2013-9