A meta-analysis of the association between BRAF mutation and nonsmall cell lung cancer

作者：Cui, Guanghui; Liu, Donglei; Li, Weihao; Fu, Xiao; Liang, Youguang; Li, Yuhang; Shi, Wensong; Chen, Xiaofang; Zhao, Song^*

来源：Medicine, 2017, 96(14): e6552.

DOI：10.1097/MD.0000000000006552

• BRAF
• meta-analysis
• mutation
• nonsmall cell lung cancer

Background: Previous studies investigating the association between BRAF mutations and nonsmall cell lung cancer (NSCLC) remain controversial. To address the issue, we performed an updated meta-analysis of related articles.
Methods: We conducted a comprehensive literature search in the electronic databases including ISI Science Citation Index, EMBASE, PubMed, and CNKI (up to January 2016). The odds ratios (ORs) and 95% confidence interval (CI) were assessed based on random-effects or fixed-effects models according to the heterogeneity of eligible studies.
Results: A total of 16 studies enrolled 11,711 patients with NSCLC were involved in the meta-analysis. The overall BRAF mutation rate was 2.6% (303/11,711). There was a significant association between BRAF mutations and adenocarcinomas (ADCs) in NSCLC compared with non-ADCs (OR=3.96, 95% CI=2.13-7.34, P<0.0001). No significant difference was observed in smoking and stage in patients with BRAF mutations. However, a significant difference of BRAF mutation rate was observed between women and men (OR=0.72, 95% CI=0.55-0.95, P=0.02). In addition, the BRAF(V600E) mutations were more frequent in women (OR=0.45, 95% CI=0.26-0.77, P=0.004) and never smokers (OR=0.12, 95% CI=0.05-0.29, P<0.00001).
Conclusions: BRAF mutations in ADCS and female significantly increased the risk of NSCLC compared to non-ADCS and male, respectively. BRAFV(600E) mutation in NSCLC patients was significantly associated with female and nonsmokers.

• 出版日期2017-4
• 单位郑州大学