An alternative synthesis of ((+)under-bar)-propranolol and ((+)under-bar)-atenolol

作者：Inkum Rachaneebhorn; Teerawutgulrag Aphiwat^*; Puangsombat Pakawan; Rakariyatham Nuansri

来源：Maejo International Journal of Science and Technology, 2012, 6(3): 372-378.

• beta-blockers
• propranolol
• atenolol

Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol.

• 出版日期2012-12