Molecular mechanisms in the initiation phase of Wallerian degeneration

作者：Chang Biao; Quan Qi; Lu Shibi; Wang Yu; Peng Jiang

来源：European Journal of Neuroscience, 2016, 44(4): 2040-2048.

DOI：10.1111/ejn.13250

• nicotinamide adenine dinucleotide
• nicotinamide mononucleotide
• nicotinamide mononucleotide adenylyltransferase 2
• sterile alpha and armadillo motif-containing protein 1

Axonal degeneration is an early hallmark of nerve injury and many neurodegenerative diseases. The discovery of the Wallerian degeneration slow mutant mouse, in which axonal degeneration is delayed, revealed that Wallerian degeneration is an active progress and thereby illuminated the mechanisms underlying axonal degeneration. Nicotinamide mononucleotide adenylyltransferase 2 and sterile alpha and armadillo motif-containing protein 1 play essential roles in the maintenance of axon integrity by regulating the level of nicotinamide adenine dinucleotide, which seems to be the key molecule involved in the maintenance of axonal health. However, the function of nicotinamide mononucleotide remains debatable, and we discuss two apparently conflicting roles of nicotinamide mononucleotide in Wallerian degeneration. In this article, we focus on the roles of these molecules in the initiation phase of Wallerian degeneration to improve our understanding of the mechanisms underpinning this phenomenon.

• 出版日期2016-8