A mechanism accounting for independence on starting length of tension increase in ramp stretches of active skeletal muscle at short half-sarcomere lengths

作者：Till Olaf^*; Siebert Tobias; Blickhan Reinhard

来源：Journal of Theoretical Biology, 2010, 266(1): 117-123.

DOI：10.1016/j.jtbi.2010.06.021

• Skeletal muscle
• Eccentric contraction
• Muscle model
• Simulation

Based on previous experimental results of independence on starting length of the tension gradient in constant-velocity stretches of active skeletal muscle at muscle lengths including the ascending limb and the plateau of the tension-length relation, a possible physiological mechanism determining the tension increase in lengthening active muscle is discussed. Considering the sliding filament theory, it is suggested that the tension-length relation of a half-sarcomere in lengthening contractions is different from that in isometric contractions. The assumed mechanism predicts, among others, that the thick filament retains its shortened length in lengthening contractions starting from a half-sarcomere length where this filament is compressed. An example model is implemented and checked with simulations.

• 出版日期2010-9-7