Mitochondrial heme: an exit strategy at last

作者:Fleming Mark D*; Hamza Iqbal
来源:Journal of Clinical Investigation, 2012, 122(12): 4328-4330.
DOI:10.1172/JCI66607

摘要

The transport of heme across membranes is critical for iron absorption, the formation of hemoglobin and other hemoproteins, and iron recycling in macrophages. However, the identity of heme transport proteins has been elusive. In this issue of the JCI, Chiabrando et al reveal that an isoform of the feline leukemia virus subgroup C receptor (FLVCR1) exports heme from the mitochondria and is critical for erythroid differentiation.

  • 出版日期2012-12