A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions

作者：Daemi Hamed; Rajabi Zeleti Sareh; Sardon Haritz; Barikani Mehdi^*; Khademhosseini Ali; Baharvand Hossein

来源：Biomaterials, 2016, 84: 54-63.

DOI：10.1016/j.biomaterials.2016.01.025

• Supramolecular elastomer
• Alginate
• Load-bearing tissue
• Self-healing
• Biodegradation
• Vascular tissue engineering

Alginate-based supramolecular ionic polyurethanes (ASPUs) as mechanically tunable biomaterials with high strength and toughness in both dry and hydrated states are developed under metal-free conditions. The Young's modulus and tensile strength of ASPUs are tuned from 30 to 100 MPa, and 20 to 50 MPa, respectively. Interestingly, the ASPUs exhibit a small hysteresis loop, minimal loss of tensile strength and minimal creep deformation after 100 repetitive cycles which makes them of use for engineering of load bearing tissues. This is the first report that describes a linear PU can resist a large number of cyclic stresses without significant stretching. These bio-based elastomers engineered by ionic interactions are biocompatible and biodegradable. The ASPUs demonstrate a similar in vivo degradation rate compared to polycaprolactone (PCL). These biomaterials also demonstrate a rapid self-healing and recovery after rupture, and have a linear biodegradation profile. Furthermore, histological examination of subcutaneous transplanted ASPUs after five months reveals low immunological response and low fibrosis.

• 出版日期2016-4