Murine Typhus in Southern Taiwan during 1992-2009

作者：Chang Ko; Chen Yen Hsu; Lee Nan Yao; Lee Hsin Chun; Lin Chun Yu; Tsai Jih Jin; Lu Po Liang; Chen Tun Chieh; Hsieh Hsiao Chen; Lin Wei Ru; Lai Ping Chang; Chang Chia Ming; Wu Chi Jung; Lai Chung Hsu; Ko Wen Chien^*

来源：The American Journal of Tropical Medicine and Hygiene, 2012, 87(1): 141-147.

DOI：10.4269/ajtmh.2012.11-0465

Clinical information regarding murine typhus in Taiwan is limited. In this study, 81 cases of serologically documented murine typhus during 1992-2009 at four referral hospitals in southern Taiwan were analyzed. There was a significant correlation between average environmental temperature and case numbers of murine typhus (r = 0.747, P = 0.005). Acute hepatitis was found in 67% of cases, and hyperbilirubinemia (serum total bilirubin %26gt;= 23.9 mu mol/L) was found in 38%. The intervals between the initiation of appropriate therapy to defervescence were longer in patients with hyperbilirubinemia than those without hyperbilirubinemia (6.1 versus 4.1 days; P = 0.015). Nine (11.1%) showed development of severe illnesses such as acute respiratory distress syndrome (2 patients), aseptic meningitis (3), and acute renal failure (4). Only one died of acute respiratory distress syndrome. Cases of murine typhus were often found during the summer and had acute febrile hepatitis. Those patients with hyperbilirubinemia tended to have a delayed recovery even with appropriate therapy.

• 出版日期2012-7
• 单位河北医科大学