科研之友
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摘要
Baliospermum montanum leaves yielded 3-hydroxy-2,4-dimethoxy- 10-methyl-9-acridanone (1), an alkaloid from the CHCl3 fraction. Spectroscopic analysis was performed to assign the structure of the new compound (1) and its absolute configuration. The compound was evaluated for its effect in anaphylaxis by estimation of the release of histamine in systemic anaphylaxis model. The acridanone alkaloid significantly inhibited the degranulation of mast cells up to 65.22% and 75.12% at a dose of 50 and 75mg/kg, respectively.
- 出版日期2011-11
