Assessing sinus aerosol deposition: Benefits of SPECT-CT imaging

作者：Leclerc Lara^*; Pourchez Jeremie; Prevot Nathalie; Vecellio Laurent; Le Guellec Sandrine; Cottier Michele; Durand Marc

来源：International Journal of Pharmaceutics, 2014, 462(1-2): 135-141.

DOI：10.1016/j.ijpharm.2013.12.032

• Aerosol therapy
• Aerosol deposition
• SPECT/CT imaging

Purpose: Aerosol inhalation therapy is one of the methods to treat rhinosinusitis. However the topical drug delivery to the posterior nose and paranasal sinuses shows only limited efficiency. A precise sinusal targeting remains a main challenge for aerosol treatment of sinus disorders. This paper proposes a comparative study of the nasal deposition patterns of micron and submicron particles using planar gamma-scintigraphy imaging vs. a new 3-dimensional (3D) imaging approach based on SPECT-CT measurements.
Methods: Radiolabelled nebulizations have been performed on a plastinated model of human nasal cast coupled with a respiratory pump. First, the benefits provided by SPECT-CT imaging were compared with 2D gamma-scintigraphy and radioactive quantification of maxillary sinus lavage as reference for the sonic 2.8 mu m aerosol sinusal deposition. Then, the impact on nasal deposition of various airborne particle sizes was assessed.
Results: The 2D methodology overestimates aerosol deposition in the maxillary sinuses by a factor 9 whereas the 3D methodology is in agreement with the maxillary sinus lavage reference methodology. Then with the SPECT-CT approach we highlighted that the higher particle size was mainly deposited in the central nasal cavity contrary to the submicron aerosol particles (33.8 +/- 0.6% of total deposition for the 2.8 mu m particles vs. 1 +/- 0.3% for the 230 nm particles).
Conclusion: Benefits of SPECT/CT for the assessment of radiolabelled aerosol deposition in rhinology are clearly demonstrated. This 3D methodology should be preferentially used for scintigraphic imaging of sinusal deposition in Human.

• 出版日期2014-2-28