Au Nanoparticle/DNA Rotaxane Hybrid Nanostructures Exhibiting Switchable Fluorescence Properties

作者：Cecconello Alessandro; Lu Chun Hua; Elbaz Johann; Willner Itamar^*

来源：Nano Letters, 2013, 13(12): 6275-6280.

DOI：10.1021/nl403884w

• DNA
• rotaxane
• machine
• nanoparticle
• fluorescence
• switch

The preparation of a DNA rotaxane consisting of a circular nucleic acid interlocked, through hybridization, on a nucleic acid axle and stoppered by two 10-nm-sized Au nanoparticles (NPs) is described. By the tethering of 5-nm- or 15-nm-sized Au NPs on the ring, the supramolecular structure of the rotaxane is confirmed. Using nucleic acids as "fuels" and "anti-fuels", the cyclic and reversible transition of the rotaxane ring across two states is demonstrated. By the fiinctionalization of the ring with fluorophore-modified nucleic acids in different orientations, the transitions of the rings between the sites are followed by fluorescence quenching or surface-enhanced fluorescence. The experimental results are supported by theoretical modeling.

• 出版日期2013-12