A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

作者：Battilocchio Claudio; Hawkins Joel M; Ley Steven V^*

来源：Organic Letters, 2013, 15(9): 2278-2281.

DOI：10.1021/ol400856g

A flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6-75 min). In three examples the system was scaled to deliver 50 mmol of product.

• 出版日期2013-5-3