Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden

作者：Nickel T^*; Vogeser M; Emslander I; David R; Heilmeier B; den Winkel M Op; Schmidt Trucksaess A; Wilbert Lampen U; Hanssen H; Halle M

来源：Atherosclerosis, 2012, 220(1): 219-222.

DOI：10.1016/j.atherosclerosis.2011.09.036

• Marathon running
• Stress
• Chromogranin A
• proBNP
• Troponin T

Objective: Stress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress. %26lt;br%26gt;Methods: We recruited 47 lean and obese runners for a 10 week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA. %26lt;br%26gt;Results: We found a significant increase of CGA (+51%; p %26lt; 0.01) in lean runners after marathon. The obese group showed the highest troponin T (0.22 ng/ml; p %26lt; 0.01) and proBNP (176.6 ng/ml; p %26lt; 0.01) levels. There were no correlations between proBNP, troponin T and CGA. An inverse correlation (r = -0.45; p %26lt; 0.01) was found between CGA and finishing times. %26lt;br%26gt;Conclusion: Marathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress.

• 出版日期2012-1