No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

作者：Thyagarajan Bharat; Anderson Kristin E; Folsom Aaron R; Jacobs David R Jr; Lynch Charles F; Bargaje Archana; Khaliq Waseem; Gross Myron D^*

来源：Cancer Detection and Prevention, 2006, 30(4): 313-321.

DOI：10.1016/j.cdp.2006.07.002

• postmenopausal breast cancer
• polymorphisms
• DNA repair
• base excision repair
• double strand DNA repair
• nested case control study
• IWHS
• INVADER assay
• paraffin embedded tissue
• genotype
• Arg399Gln
• BMI
• risk factors
• statistical analysis

Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER. or Sequenom. Results: None. of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

• 出版日期2006