Association of N-Acetylaspartate and Cerebrospinal Fluid A beta(42) in Dementia

作者：Jessen Frank^*; Lewczuk Piotr; Guer Okan; Block Wolfgang; Ende Gabriele; Froelich Lutz; Hammen Thilo; Arlt Soenke; Kornhuber Johannes; Kucinski Thomas; Popp Julius; Peters Oliver; Maier Wolfgang; Traeber Frank; Wiltfang Jens

来源：Journal of Alzheimer's Disease, 2011, 27(2): 393-399.

DOI：10.3233/JAD-2011-110398

• Alzheimer's disease
• amyloid-beta(42)
• N-acetylaspartate
• medial temporal lobe
• mitochondria
• proton MR spectrocopy

The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-beta(42) (A beta(42)), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A beta(42) within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and A beta(42) may reflect the interaction between disrupted mitochondrial pathways and amyloid production.

• 出版日期2011
• 单位上海市精神卫生中心