A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil

作者：An, Li-Jun; Zhang, Yang; Su, Zheng; Zhang, Xian-Long; Liu, Hai-Lin; Zhang, Zhi-Jie; Hu, Jian-Lin; Li, Shi-Tong^*

来源：BMC Anesthesiology, 2017, 17(1): 154.

DOI：10.1186/s12871-017-0446-8

• Dezocine
• Emergence agitation
• Preschool children
• Sevoflurane-remifentanil

Background: Emergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.
Methods: A total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C (n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0.1 mg/kg, postoperatively.
Results: Incidence of EA, defined as a score >= 3 on Aono's four point scale or Pediatric Anesthesia Emergence Delirium (PAED) score >= 10 in the PACU (10% vs. 76%) and the percentage of patients with severe EA (PAED score >= 13) (12% vs. 76%) were significantly lower in Group D compared to Group C (P < 0.05). Mean Children and Infants Postoperative Pain Scale (CHIPPS) score was significantly lower in Group D compared to Group C (1.2 +/- 0.5 vs. 5.2 +/- 0.6; P < 0.05). Patients need for fentanyl (18% vs. 4%) or propofol rescue (20% vs. 0) was significantly greater in Group C compared to Group D. No significant differences in other relative aspects after surgery between groups.
Conclusion: Administration of dezocine 0.1 mg/kg decreased the incidence and severity of EA in preschool children that had undergone laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia.

• 出版日期2017-11-22
• 单位南京医科大学