A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis

作者：Tung Gia Phan; Messacar Kevin; Dominguez Samuel R; da Costa Antonio Charlys; Deng Xutao; Delwart Eric^*

来源：Archives of Virology, 2016, 161(11): 3231-3235.

DOI：10.1007/s00705-016-3002-9

We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.

• 出版日期2016-11