Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens

作者：Burton Oliver T; Gibbs Sarah; Miller Nigel; Jones Frances M; Wen Li; Dunne David W; Cooke Anne; Zaccone Paola^*

来源：European Journal of Immunology, 2010, 40(8): 2221-2229.

DOI：10.1002/eji.200939998

• Foxp3 Treg
• NOD mice
• Schistosoma mansoni antigens
• TGF-beta
• TLR

The immunomodulatory effect of Schistosoma mansoni antigens has often been attributed to interaction with PRR expressed on APC. Our previous work has shown that S. mansonisoluble egg antigen (SEA) can induce, together with a Th2 response, TGF-beta-dependent Foxp3 expression in nave CD4(+) T cells from NOD mice. We found that SEA can directly upregulate the expression of surface-bound TGF-beta in purified CD4(+) T cells in the absence of accessory cell interactions. In this study, we show that the C-type lectin receptors DEC-205 and galectin-3 were involved in the direct interaction between S. mansoni antigens and CD4(+) T cells. SEA was able to enhance CD4(+) T-cell secretion of bioactive TGF-beta in response to TLR2 ligand stimulation, in the absence of APC. We also show that TLR2 expressed on CD4(+) T cells was important for the Foxp3 expression induced by SEA.

• 出版日期2010-8