Assessing Bioenergetic Compromise in Autism Spectrum Disorder With P-31 Magnetic Resonance Spectroscopy: Preliminary Report

作者：Golomb Beatrice A^*; Erickson Laura C; Scott Van Zeeland Ashley A; Koperski Sabrina; Haas Richard H; Wallace Douglas C; Naviaux Robert K; Lincoln Alan J; Reiner Gail E; Hamilton Gavin

来源：Journal of Child Neurology, 2014, 29(2): 187-193.

DOI：10.1177/0883073813498466

• autism spectrum disorder
• P-31-MRS
• brain
• muscle
• bioenergetics

We sought to examine, via Phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) in a case-control design, whether bioenergetic deficits in autism spectrum disorders extend to the brain and muscle. Six cases with autism spectrum disorder with suspected mitochondrial dysage 6-18 years) and 6 age/sex-matched controls underwent P-31 magnetic resonance spectroscopy. The outcomes of focus were muscle resting phosphocreatine and intracellular pH as well as postexercise phosphocreatine recovery time constant and frontal brain phosphocreatine. Intracellular muscle pH was lower in each autism spectrum disorder case than their matched control (6/6, P = .03; P = .0048, paired t test). Muscle phosphocreatine (5/6), brain phosphocreatine (3/4), and muscle phosphocreatine recovery time constant (3/3) trends were in the predicted direction (not all participants completed each). This study introduces P-31 magnetic resonance spectroscopy as a noninvasive tool for assessment of mitochondrial function in autism spectrum disorder enabling bioenergetic assessment in brain and provides preliminary evidence suggesting that bioenergetic defects in cases with autism spectrum disorder are present in muscle and may extend to brain.

• 出版日期2014-2