Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb(2 )) exposure

作者：Zhang Le Feng; Peng Shuang Qing^*; Wang Sheng

来源：Toxicology Letters, 2009, 186(2): 78-83.

DOI：10.1016/j.toxlet.2009.01.004

• Lead (Pb(2 )) toxicity
• Hypertension
• Aorta
• Vascular reactivity
• 5-HT
• Structure

Male Wistar rats were exposed to 100 ppm Pb(2 ) in drinking water for 10 months. Tail blood pressure, serum 5-hydroxytryptamine (5-HT), the expression of 5-HT(2B) receptor in the aorta, the aortic response to 5-HT, and the pathologic changes of aorta were examined. The systolic blood pressure of Pb(2 ) exposed group was significantly increased after 2 months of Pb(2 ) exposure. After 10 months of Pb(2 ) exposure, aortic contractile response to 5-HT was significantly decreased. There was no significant difference in the levels of serum 5-HT and the expression of 5-HT(2B) receptor between these two groups. The aortic media and the media-lumen ratio of Pb(2 ) exposed group were significantly increased. These data suggest that long-term Pb(2 ) exposure can increase blood pressure, and can alter the function and structure of aortic of rats. The decreased aortic response to 5-HT has little relation to the expression of 5-HT(2B) receptor and the serum level of 5-HT, maybe is a result of the aortic structural alteration.

• 出版日期2009-4-25
• 单位中国人民解放军军事医学科学院; 北京大学; 首都医科大学