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摘要
Purpose: We tested the hypothesis that the maximal lactate steady state (MLSS) can be accurately determined in healthy subjects based on measures of deoxygenated hemoglobin (deoxyHb), an index of oxygen extraction measured noninvasively by near-infrared spectroscopy (NIRS). Methods: Thirty-two healthy men (mean +/- SD age = 48 +/- 17 yr, range = 23-74 yr) performed an incremental cycling test to exhaustion and square wave tests for MLSS determination. Cardiorespiratory variables were measured bbb and deoxyHb was monitored noninvasively on the right vastus lateralis with a quantitative NIRS device. The individual values of (V)over dotO(2) and HR corresponding to the MLSS were calculated and compared to the NIRS-derived MLSS (NIRSMLSS) that was, in turn, determined by double linear function fitting of deoxyHb during the incremental exercise. Results: (V)over dotO(2) and HR at MLSS were 2.25 +/- 0.54 L.min(-1) (76% +/- 9% (V)over dotO(2max)) and 133 +/- 14 bpm (81% +/- 7% HRmax), respectively. Muscle O-2 extraction increased as a function of exercise intensity up to a deflection point, NIRSMLSS, at which (V)over dotO(2) and HR were 2.23 +/- 0.59 L.min(-1) (76% +/- 9% (V)over dotO(2max)) and 136 +/- 17 bpm (82% +/- 8% HRmax), respectively. For both (V)over dotO(2) and HR, the difference of NIRSMLSS from MLSS values was not significant and the measures were highly correlated (r(2) = 0.81 and r(2) = 0.76). The Bland-Altman analysis confirmed a nonsignificant bias for (V)over dotO(2) and HR (-0.015 L.min(-1) and 3 bpm, respectively) and a small imprecision of 0.26 L.min(-1) and 8 bpm. Conclusions: A plateau in muscle O-2 extraction was demonstrated in coincidence with MLSS during an incremental cycling exercise, confirming the hypothesis that this functional parameter can be accurately estimated with a quantitative NIRS device. The main advantages of NIRSMLSS over lactate-based techniques are the noninvasiveness and the time/cost efficiency.
- 出版日期2013-6
