Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

作者：Tuncel Sinem; Trivella Aurelien; Atilla Devrim; Bennis Khalil; Savoie Huguette; Albrieux Florian; Delort Laetitia; Billard Hermine; Dubois Virginie; Ahsen Vefa; Caldefie Chezet Florence; Richard Claire; Boyle Ross W; Ducki Sylvie; Dumoulin Fabienne^*

来源：Molecular Pharmaceutics, 2013, 10(10): 3706-3716.

DOI：10.1021/mp400207v

• phthalocyanine
• chalcone
• photodynamic therapy
• antivascular
• dual effect

Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.

• 出版日期2013-10