Spaceflight induced changes in the human proteome

作者：Kononikhin Alexey S; Starodubtseva Natalia L; Pastushkova Lyudmila Kh; Kashirina Daria N; Fedorchenko Kristina Yu; Brhozovsky Alexander G; Popov Igor A; Larina Irina M; Nikolaev Evgeny N

来源：Expert Review of Proteomics, 2017, 14(1): 15-29.

DOI：10.1080/14789450.2017.1258307

• Spaceflight
• proteomics
• extreme conditions
• human proteome
• MARS 500
• bed rest study
• dry immersion
• microgravity
• spaceflight simulation

Introduction: Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts.
Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments.
Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.

• 出版日期2017