Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease

作者：Moller Christiane; Hafkemeijer Anne; Pijnenburg Yolande A L; Rombouts Serge A R B; van der Grond Jeroen; Dopper Elise; van Swieten John; Versteeg Adriaan; Steenwijk Martijn D; Barkhof Frederik; Scheltens Philip; Vrenken Hugo; van der Flier Wiesje M^*

来源：Neurobiology of Aging, 2016, 38: 21-31.

DOI：10.1016/j.neurobiolaging.2015.10.020

• Alzheimer's disease
• Behavioral variant frontotemporal dementia
• Gray matter thickness
• Longitudinal
• Cognition

We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 +/- 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.

• 出版日期2016-2