A Convenient Synthesis of 3,7 '-Bisindole Derivatives

作者：Liu, Teng; Zhu, Hong-You; Luo, Da-Yun; Yan, Sheng-Jiao^*; Lin, Jun^*

来源：Molecules, 2016, 21(5): 638.

DOI：10.3390/molecules21050638

• 3,7 '-bisindoles
• Michael addition
• condensation reaction
• heterocyclic ketene aminals

An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7 1-bisindole derivatives in moderate to good yields.

• 出版日期2016-5
• 单位云南大学