科研之友
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摘要
Background: The association between the TERT (telomerase reverse transcriptase) rs2736100 single nucleotide polymorphism and lung cancer risk has been studied by many researchers, but the results remain inconclusive. To further explore this association, we performed a meta-analysis to further studies. Material and methods: We performed a case-control study in 554 lung cancer cases and 693 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. Afterwards a computerized search of PubMed and Google Scholar for publications on rs2736100 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between rs2736100 and lung cancer risk in 21 selected case-control studies. A sensitivity analysis, a test of heterogeneity, a cumulative meta-analysis, and an assessment of bias were also performed. Results: In our study, we found that rs2736100 GT-GG increased the risk of lung in the dominant model (OR = 1.48, 95% CI: 1.13-1.94). In the meta-analysis, a significant association between the rs273610 polymorphism and lung risk was observed (OR = 1.225, 95% CI: 1.170-1.283 C vs. A; OR = 1.325, 95% CI: 1.285-1.365 for AC+CC vs. AA; OR = 1.324, 95% CI: 1.225-1.431 for CC vs. AA+AC), and further stratifications demonstrated a moderately increased risk for lung in Asian ethnicity studies. Conclusions: Our results and the meta-analysis suggest that the rs2736100 polymorphism may contribute to the risk of lung cancer in the Chinese population and Asian population.
