科研之友
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摘要
A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1 alpha, leading to activation of the proinflammatory cytokine IL-1 beta.
- 出版日期2013-6-4
