Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: Evaluation of efficacy and tolerability

作者：Brodie Martin J^*; French Jacqueline A; McDonald Susan A; Lee Wen Jene; Adams Bryan; Scott Andrew; Nohria Virinder; DeRossett Sarah

来源：Epilepsy Research, 2014, 108(5): 989-994.

DOI：10.1016/j.eplepsyres.2014.03.008

• Retigabine
• Ezogabine
• Antiepileptic drugs
• Tolerability
• Efficacy
• Rational polytherapy

Integrated data from three double-blind, randomized, placebo-controlled trials were analyzed to evaluate the efficacy and tolerability of ezogabine (EZG; US adopted name)/retigabine (RTG; international non-proprietary name) when used in combination with >= 1 sodium channel blocking antiepileptic drug (AED), >= 1 non-sodium channel blocking AED, or >= 1 AED from both the sodium channel and non-sodium channel mechanistic groups. Efficacy and tolerability appeared to be similar across all three groups of patients.

• 出版日期2014-7