Apparent Diffusion Coefficient Value Is Not Dependent on Magnetic Resonance Systems and Field Strength Under Fixed Imaging Parameters in Brain

作者：Ogura Akio^*; Tamura Takayuki; Ozaki Masanori; Doi Tsukasa; Fujimoto Koji; Miyati Tosiaki; Ito Yukiko; Maeda Fumie; Tarewaki Hiroyuki; Takahashi Mitsuyuki

来源：Journal of Computer Assisted Tomography, 2015, 39(5): 760-765.

DOI：10.1097/RCT.0000000000000266

• apparent diffusion coefficient
• signal-to-noise ratio
• b value
• coefficient of variation of ADC
• different field strength

Objective The aim of the study was to investigate the causes of apparent diffusion coefficient (ADC) measurement errors and to determine the optimal scanning parameters that are independent of the field strength and vendors of the magnetic resonance (MR) system.
Materials and Methods Brain MR images of 10 healthy volunteers were scanned using 6 MR scanners of different field strengths and vendors in 2 different institutions. Ethical review board approvals were obtained for this study, and all volunteers gave their informed consents. Coefficient of variation (CV) of ADC values were compared for their differences in various MR scanners and in the scanned subjects.
Results The CV of ADC values for 6 different scanners of 6 brains was 3.32%. The CV for repeated measurements in 1 day (10 scans per day) and in 10 days (scan per day for 10 days) for 1 subject was 1.72% and 2.96%, respectively (n = 5, P < 0.001). The CV of measurements for 10 healthy subjects was 5.22%. The measurement errors of the ADC values for 6 different MR units in 1 subject were higher than the intrascanner variance for the same subject but were lower than the intersubject variance for the same scanner.
Conclusions The variance in the ADC values for different MR scanners is reasonably small if appropriate scanning parameters (repetition time, >3000 ms; echo time, minimum; and high enough signal-to-noise ratio of high-b diffusion-weighted image) are used.

• 出版日期2015-10
• 单位河北医科大学