Development of olmesartan medoxomil lipid-based nanoparticles and nanosuspension: preparation, characterization and comparative pharmacokinetic evaluation

作者：Arun B; Narendar D; Veerabrahma Kishan^*

来源：Artificial Cells Nanomedicine and Biotechnology, 2018, 46(1): 126-137.

DOI：10.1080/21691401.2017.1299160

• Olmesartan medoxomil
• solid lipid nanoparticles
• nanosuspension
• pharmacokinetics
• bioavailability

The aim was to enhance the oral bioavailability of olmesartan medoxomil (OM) by preparing solid lipid nanoparticles (SLNs) and comparing with nanosuspension (OM-NS). OM-SLNs and OM-NS were prepared by known methods. Prepared SLNs were evaluated for physical characters and in vivo pharmacokinetic (PK) performance in rats. OM-NS showed more than four-fold increase in the solubility. During DSC and XRD studies, drug incorporated in SLNs was found to be in amorphous form. The relative bioavailability of OM-SLN and OM-NS was 7.21- and 3.52-fold when compared with that of coarse suspension. Further, OM-SLNs also increased the oral bioavailability by two-fold over that of OM-NS.

• 出版日期2018