A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer

作者：Shabason Jacob E; Chen Jerry; Apisarnthanarax Smith; Damjanov Nevena; Giantonio Bruce; Loaiza Bonilla Arturo; O'Dwyer Peter J; O'Hara Mark; Reiss Kim A; Teitelbaum Ursina; Wissel Paul; Drebin Jeffrey A; Vollmer Charles; Kochman Michael; Mick Rosemarie; Vergara Norge; Jhala Nirag; Doucette Abigail; Lukens John N; Plastaras John P; Metz James M; Ben Josef Edgar

来源：Cancer Chemotherapy and Pharmacology, 2018, 81(3): 609-614.

DOI：10.1007/s00280-018-3519-6

• Pancreatic Cancer
• Nab-paclitaxel
• Abraxane
• Chemoradiation

Patients with locally advanced pancreatic cancer typically have poor outcomes, with a median survival of approximately 16 months. Novel methods to improve outcomes are needed. Nab-paclitaxel (Abraxane) has shown efficacy in pancreatic cancer and is FDA-approved for metastatic disease in combination with gemcitabine. Nab-paclitaxel is also a promising radiosensitizer based on laboratory studies, but it has never been clinically tested with definitive radiotherapy for locally advanced pancreatic carcinoma.
We performed a phase 1 study using a 3 + 3 dose escalation strategy to determine the safety and tolerability of dose-escalated nab-paclitaxel with fractionated radiotherapy for patients with unresectable or borderline resectable pancreatic cancer. Following induction chemotherapy with two cycles of nab-paclitaxel and gemcitabine, patients were treated with weekly nab-paclitaxel and daily radiotherapy to a dose of 52.5 Gy in 25 fractions. Final dose-limiting toxicity (DLT) determination was performed at day 65 after the start of radiotherapy.
Nine patients received nab-paclitaxel at a dose level of either 100 mg/m(2) (n = 3) or 125 mg/m(2) (n = 6). There were no observed grade 3 gastrointestinal toxicities. One DLT (grade 3 neuropathy) was observed in a patient who received 125 mg/m(2) of nab-paclitaxel. Other grade 3 toxicities included fatigue (11%), anemia (11%) and neutropenia (11%). No grade 4 toxicities were observed. Following chemoradiotherapy, four patients (borderline resectable, n = 2 and unresectable, n = 2) underwent surgical resection, all with negative margins and with significant treatment effect with limited tumor viability.
The combination of fractionated radiation and weekly full dose nab-paclitaxel was safe and well-tolerated.

• 出版日期2018-3