Direct comparison of in vivo versus postmortem second-order motion-compensated cardiac diffusion tensor imaging

作者：Stoeck Christian T; von Deuster Constantin; Fleischmann Thea; Lipiski Miriam; Cesarovic Nikola; Kozerke Sebastian^*

来源：Magnetic Resonance in Medicine, 2018, 79(4): 2265-2276.

DOI：10.1002/mrm.26871

• diffusion tensor Imaging
• cardiac DTI
• second-order motion-compensated DTI
• cardiac myofiber arrangement
• in vivo
• postmortem

PurposeTo directly compare in vivo versus postmortem second-order motion-compensated spin-echo diffusion tensor imaging of the porcine heart.
MethodsSecond-order motion-compensated spin-echo cardiac diffusion tensor imaging was performed during systolic contraction in vivo and repeated upon cardiac arrest by bariumchloride without repositioning of the study animal or replaning of imaging slices. In vivo and postmortem reproducibility was assessed by repeat measurements. Comparison of helix, transverse, and sheet (E2A) angulation as well as mean diffusivity and fractional anisotropy was performed.
ResultsIntraclass correlation coefficients for repeated measurements (postmortem/in vivo) were 0.95/0.96 for helix, 0.70/0.66 for transverse, and 0.79/0.72 for E2A angulation; 0.83/0.72 for mean diffusivity; and 0.78/0.76 for fractional anisotropy. The corresponding 95% levels of agreement across the left ventricle were: helix 14 to 18 degrees/12 to 15 degrees, transverse 9 to 10 degrees/10 to 11 degrees, E2A 15 to 20 degrees/16 to 18 degrees. The 95% levels of agreement across the left ventricle for the comparison of postmortem versus in vivo were 20 to 22 degrees for helix, 13 to 19 degrees for transverse, and 24 to 31 degrees for E2A angulation.
ConclusionsParameters derived from in vivo second-order motion-compensated spin-echo diffusion tensor imaging agreed well with postmortem imaging, indicating sufficient suppression of motion-induced signal distortions of in vivo cardiac diffusion tensor imaging. Magn Reson Med 79:2265-2276, 2018.

• 出版日期2018-4