Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus

作者：Demirci F Yesim K; Manzi Susan; Ramsey Goldman Rosalind; Kenney Margaret; Shaw Penny S; Dunlop Thomas Charmayne M; Kao Amy H; Rhew Elisa Y; Bontempo Franklin; Kammerer Candace; Kamboh M Ilyas^*

来源：Journal of Rheumatology, 2007, 34(8): 1708-1711.

• TLR5
• TLR9
• Toll-like receptor
• lupus
• systemic lupus erythematosus

Objective. Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR5 (Arg392Stop, rs5744168) and TLR9 (-1237T -> C, rs5743836) single nucleotide polymorphisms (SNP) with systemic lupus erythematosus (SLE) in Caucasian American subjects.
Methods. We performed a case-control association study and genotyped 409 Caucasian women with allelic discrimination (rs5744168) or SLE and 509 Caucasian healthy female controls usim, TaqMan (R) polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836).
Results. None of the 2 TLR SNP showed a statistically significant association with SLE risk in our cohort.
Conclusion. Our results do not indicate a major influence of these putative functional TLR SNP on the susceptibility to (or protection from) SLE.

• 出版日期2007-8
• 单位西北大学