An efficient and simple Morita-Baylis-Hillman reaction based on the N-methylpyrrolidine-Ba(OH)(2) catalytic system

作者：Guerra Krassimira P; Afonso Carlos A M^*

来源：Tetrahedron, 2011, 67(14): 2562-2569.

DOI：10.1016/j.tet.2011.02.020

• Water
• Cooperative catalysis
• Enone
• Formaldehyde
• N-Methylpyrrolidine
• MBH reaction

By using of precise catalytic amount of N-methylpyrrolidine (5 mol %) and Ba(OH)(2) (1.5 mol %) in H2O/CH3OH 5/1 or CH3OH/CH2Cl2 3/1 solvent mixtures at T=0 degrees C a Morita-Baylis-Hillman derivatives could be obtained in good to excellent yield from 2-cyclopenten-1-one, 2-cyclohexen-1-one and formaldehyde and diverse aryl aldehydes after suitable reaction time.

• 出版日期2011-4-8