A New Azwafluorenone from the Roots of Polyalthia cerasoides and its Biological Activity

作者：Pumsalid Kanchana; Thaisuchat Haruthai; Loetchutinat Chatchanok; Nuntasaen Narong; Meepowpan Puttinan; Pompimon Wilart^*

来源：Natural Product Communications, 2010, 5(12): 1931-1934.

• Polyalthia cerasoides
• Annonaceae
• azafluorenone
• antimycobacterial activity
• cytotoxicity

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-l-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC(50) values in the range of 2.64-3.58 mu g.mL(-1) for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M tuberculosis using a broth microdilution method, with an MIC value of 0.78 mu g.mL(-1), which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control.

• 出版日期2010-12