Hg2+-selective fluorogenic signaling probe based on the hydrolysis of hydrazone

作者：Choi Myung Gil; Ryu Hyein; Han Min Su^*; Chang Suk Kyu^*

来源：Tetrahedron Letters, 2016, 57(39): 4360-4363.

DOI：10.1016/j.tetlet.2016.08.048

• Hg2+ ions
• Fluorescence signaling
• Hydrazone hydrolysis
• Methoxynaphthaldehyde
• Smartphone

A simple Hg2+ elective fluorogenic signaling probe based on methoxynaphthalene hydrazone was investigated. Hydrazone 1 gave prominent fluorescent signals in response to Hg2+ ions in a 1:1 mixture of acetate buffer (pH 4.8) and DMSO. The fluorescence signaling was due to the Hg2+-selective hydrolysis of hydrazone to afford the strongly fluorescent methoxynaphthaldehyde. Hg2+-selective signaling of 1 was not affected by the presence of representative metal ions as the background. Hg2+-selective fluorescence signaling by 1 was possible with a detection limit of 6.0 x 10(-6) M. As a practical application, convenient detection of Hg2+ ions using a smartphone as a portable signaling processor was conducted.

• 出版日期2016-9-28