Magnetic resonance diffusion tensor imaging metrics in perilesional white matter among children with periventricular nodular gray matter heterotopia

作者：Filippi Christopher G^*; Maxwell Aaron W P; Watts Richard

来源：Pediatric Radiology, 2013, 43(9): 1196-1203.

DOI：10.1007/s00247-013-2677-2

• Diffusion tensor imaging
• Magnetic resonance imaging
• Fractional anisotrophy
• Radial diffusivity
• Periventricular nodular heterotopic gray matter
• Children

Despite pharmacological and surgical interventions, some children with periventricular nodular heterotopia (PNH) remain refractory to treatment, which suggests more diffuse pathology potentially involving perilesional white matter. %26lt;br%26gt;The purpose of this study was to evaluate MR diffusion tensor imaging (MRDTI) metrics within perilesional white matter in children with PNH. %26lt;br%26gt;Six children with PNH (four boys; average age 3.2 years, range 2 months to 6 years) were studied with MRDTI at 3 T. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were quantified within perilesional white matter at distances of 5 mm, 10 mm, 15 mm, and 20 mm from focal areas of PNH and compared to location-matched ROIs in six healthy control patients (two boys, average age 3.3 years, range 2-6 years). Statistical significance was set at an overall level of alpha = 0.05, corrected for multiple comparisons. %26lt;br%26gt;Perilesional white matter showed significantly decreased fractional anisotropy and elevated mean and radial diffusivity at all evaluated distances. No significant differences in axial diffusivity were detected at any distance. %26lt;br%26gt;PNH is associated with microstructural white matter abnormalities as indicated by abnormal perilesional MRDTI metrics detectable at least 20 mm from visible nodular lesions.

• 出版日期2013-9