Autophagy-assisted antigen cross-presentation Autophagosome as the argo of shared tumor-specific antigens and DAMPs

作者:Yi Yongxiang; Zhou Zhenxian; Shu Su; Fang Yuan; Twitty Chris; Hilton Traci L; Aung Sandra; Urba Walter J; Fox Bernard A; Hu Hong Ming*; Li Yuhuan
来源:OncoImmunology, 2012, 1(6): 976-978.
DOI:10.4161/onci.20059

摘要

It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.

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