Dosing interval of 24 hours versus 48 hours between mifepristone and misoprostol administration for mid-trimester termination of pregnancy

作者：Chaudhuri Picku^*; Mandal Apurba; Das Chandana; Mazumdar Arindam

来源：International Journal of Gynecology & Obstetrics, 2014, 124(2): 134-138.

DOI：10.1016/j.ijgo.2013.08.009

• Dosing interval
• Mifepristone
• Misoprostol
• Second trimester
• Termination of pregnancy

Objective: To compare the efficacy of a shorter interval (24 hours) between misoprostol and mifepristone administration with that of the conventional dosing interval (48 hours) for second-trimester termination of pregnancy (TOP). Methods: This was a prospective randomized, controlled, open-label study of 98 healthy women opting for mid-trimester TOP. The women were randomized to receive 200 mg mifepristone orally, followed 24 hours (Group 1) or 48 hours (Group 2) later by misoprostol (800 mu g, then 400 mu g every 3 hours). The primary outcome measure was the percentage of successful abortions within 24 hours. Secondary outcome measures were the induction-to-abortion interval (measured from misoprostol administration) and the frequencies of complications and adverse effects. Results: The rate of successful abortions was similar with the 24-hour and 48-hour dosing intervals (95.8% and 93.6%, respectively; P = 0.38). The mean induction-to-abortion interval was also comparable between the 2 groups (8.6 +/- 4.1 hours versus 8.7 +/- 3.9 hours; P = 037). Nulliparous women and women with a pregnancy duration of 16 weeks or more had a longer induction-to-abortion interval in both groups. Conclusion: The 24-hour dosing interval between misoprostol and mifepristone administration seems to be as effective as the 48-hour dosing interval for second trimester TOP.

• 出版日期2014-2