Disarray of glomerular and tubular cell adhesion molecules in the course of experimental Bothrops moojeni envenomation

作者：Collares Buzato Carla Beatriz; da Cruz Hoefling Maria Alice^*

来源：Toxicon, 2014, 78: 41-46.

DOI：10.1016/j.toxicon.2013.11.013

• Acute kidney injury
• Bothropic envenomation
• Cell adhesion proteins
• Cytoskeletal proteins
• Glomerular injury
• Nephron tubular injury

In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury.

• 出版日期2014-2