Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates

作者：Savmarker Jonas; Rydfjord Jonas; Gising Johan; Odell Luke R; Larhed Mats^*

来源：Organic Letters, 2012, 14(9): 2394-2397.

DOI：10.1021/ol300813c

A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O2CCF3), 6-methyl-2,2%26apos;-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.

• 出版日期2012-5-4