科研之友
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摘要
A novel chiral (salen)Al(III) complex was synthesized through the reaction of Et(2)AlCl and salen (R,R)-1 derived from (R,R)11,12-diamino-9,10-dihydro-9,10-ethanoanthracene. This complex is an efficient catalyst for the asymmetric trimethyl-silylcyanation of aldehydes in the presence of tributylphosphane oxide as an additive. The use of 1 mol-% of the complex led to the corresponding cyanohydrins in high yields (85-94 %) with good-to-excellent enantioselectivities (42-92 % ee).
- 出版日期2008-3
- 单位南开大学
