Anti-cytomegalovirus antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans

作者：Jeong Su Jin; Ku Nam Su; Han Sang Hoon; Choi Jun Yong; Kim Chang Oh^*; Song Young Goo; Kim June Myung

来源：Clinica Chimica Acta, 2015, 445: 65-69.

DOI：10.1016/j.cca.2015.03.015

• Cytomegalovirus
• Carotid atherosclerosis
• Inflammatory cytokines
• Elderly patients

Background: Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytolcine production in elderly Koreans.
Methods: Participants (age >= 65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT).
Results: Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p = 0.003), Framingham score (OR 1.14, p = 0.018), and levels of IL-1 beta (OR 2.96, p = 0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r = 0.523,p < 0.001), free T-4 levels (r = 0.315,p = 0.021), and Log(TNE-alpha) (r = 0.562,p < 0.001) in multivariate correlation analysis.
Conclusions: These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals.

• 出版日期2015-5-20