A new plasma biomarker enhance the clinical prediction of postoperative acute kidney injury in patients with hepatocellular carcinoma

作者：Zhou, Xing; Wang, Liyu; Wang, Guoliang; Cheng, Xiang; Hu, Shaobo; Ke, Wenbo; Li, Min; Zhang, Yong; Song, Zifang; Zheng, Qichang^*

来源：Clinica Chimica Acta, 2017, 475: 128-136.

DOI：10.1016/j.cca.2017.10.008

• Preoperative GGT/ALT
• Hepatocellular carcinoma
• Postoperative acute kidney injury
• Prediction
• Propensity score matching

Background: The ratio of serum gamma-glutamyl transferase (GGT) to alanine aminotransferase (ALT) (GGT/ALT) is a marker for evaluating effects to antivirotic treatment and a helpful predictive factor for the prognosis of Child-Pugh A hepatocellular carcinoma (HCC) patients after surgery. The relationship between the incidence of postoperative acute kidney injury (AKI) and preoperative GGT/ALT is studied in hepatectomized hepatitis B- or C- associated HCC patients. @@@ Methods: A total of 253 hepatitis B or C virus-related HCC patients undergoing hepatectomy between September 2012 and August 2016 at our hospital were included in the retrospective study. Serum ALT and GGT value were recorded, and the GGT/ALT was computed. AKI was defined that based on the "Kidney Disease Improving Global Outcomes (KDIGO) criteria". @@@ Results: AM was observed in 22 (8.7%) patients. Mean GGT/ALT of patients with AKI was significantly higher than in those without it (6.0 vs 2.1, P < 0.001). Multivariate analysis revealed an increase in GGT/ALT as an independent risk factor for AKI in hepatitis B- or C- associated HCC patients, particularly in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 or A staged HCC (odds ratio (OR) 1.400, P < 0.001). Multivariate analysis showed that ALT (OR 0.966, P = 0.044) was somewhat inversely associated with the incidence of AKI in hepatitis B- or C- associated HCC patients. The best cutoff point of GGT/ALT was 2.92. Multivariate analysis showed that preoperative GGT/ALT 2.92 predicted poor prognosis of postoperative AM in patients with HCC after hepatectomy (odds ratio 17.697, P < 0.001). After propensity score matching, preoperative GGT/ALT 2.92 remained an independent risk factor for AM in HCC patients (OR 13.947, P = 0.003). @@@ Conclusions: The GGT/ALT of patients with AM was significantly higher than those without it. Evaluation of GGT/ALT before surgery can be a helpful predictive tool for postoperative AKI in hepatitis B- or C associated HCC patients undergoing hepatectomy, particularly in patients with BCLC stage 0 or A staged HCC. Hepatitis B or C- associated HCC patients with low ALT especially within the normal range may have a high risk of AKI. However, the reason remains to be elucidated.

• 出版日期2017-12
• 单位华中科技大学